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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク EarlyBird Diabetes Study ： ウィキペディア英語版 EarlyBird Diabetes Study The EarlyBird Diabetes Study recruited 307 healthy 5y-olds randomly from Plymouth primary schools during 2000/2001, and observed them in detail at six-month intervals to the age of 16y in 2011/2012. The aim of the study was to document the natural history of metabolic health in contemporary children, many of whom are overweight or obese. The study asked the question ''Which children develop insulin resistance and why?'' and was predicated on the Accelerator Hypothesis for type 1 diabetes published in 2001.〔Wilkin TJ. The Accelerator Hypothesis: weight gain as the missing link between type 1 and type 2 diabetes Diabetologia 2001;44:914-922〕 Insulin resistance is a metabolic state, related largely (but not entirely) to obesity, that renders the tissues of the body less sensitive to insulin, and is believed to underpin the rise in diabetes, cardiovascular disease and cancer that has characterised the past 50 years.〔Reaven GM. Banting Lecture 1988. Role of insulin resistance in human disease. Diabetes 1988;37:1595-607〕 The study was directed by Professor Terry Wilkin and co-ordinated by Dr Linda Voss of Exeter University Medical School. ==Design== EarlyBird was a classic observation study of contemporary British children (1995-96 birth cohort) observed at six-month intervals over a period of 12 years from 5-16y. It combined objective measures of auxology, body composition (DEXA), physical activity (accelerometry) and metabolic rate (GEM) with annual blood samples to test a wide range of metabolic measures. By way of analogy, 300 5y-old children were lined up in rank order, the start gun was fired, and snapshots were taken every six months as the children progressed toward the finish line at 16y. Most ran straight, but many deviated out of lane towards insulin resistance and diabetes. The study was able to identify which children developed insulin resistance, and to answer in large part why. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「EarlyBird Diabetes Study」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.